Can I run the game without the CD in the drive?

In order to play, the CD must be in your CD-ROM drive upon launching Tony Hawk's Pro Skater 2.

If the CD is not in the CD-ROM drive when you launch Tony Hawk's Pro Skater 2, then a dialog box will inform you that you must insert the CD.

If you remove the CD while the game is running, the game may crash since it may be accessing the CD data.